Ys V: Kefin, The Lost City of SandEdit
Karion first appears when Adol visits Niena in her shop at the beginning of the game. He takes the medal that Stan found in the ruins of Kefin, which turns out to be the key to enter Kefin, and warns Adol to not get involved before disappearing. Karion appears again with Rije and other lieutenants after Rije uses all six crystals to break the seal on Kefin completely, causing the ancient city to appear once again.
Near the end of the game, Karion confronts Adol for the last time when the latter tries to get to the core of Kefin and destroy the Philosopher's Stone, the source of Kefin's alchemy. After the vicious battle, Karion is defeated.